ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function.

@article{Kawaguchi2003ADAM12IA,
  title={ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function.},
  author={Nobuko Kawaguchi and Christina Sundberg and Marie Kveiborg and Behzad Moghadaszadeh and Meena Asmar and Nikolaj Dietrich and Charles Kumar Thodeti and Finn Cilius Nielsen and Peter Moeller and Arthur M Mercurio and Reidar Albrechtsen and Ulla M. Wewer},
  journal={Journal of cell science},
  year={2003},
  volume={116 Pt 19},
  pages={
          3893-904
        }
}
Changes in cell shape are a morphological hallmark of differentiation. In this study we report that the expression of ADAM12, a disintegrin and metalloprotease, dramatically affects cell morphology in preadipocytes, changing them from a flattened, fibroblastic appearance to a more rounded shape. We showed that the highest levels of ADAM12 mRNA were detected in preadipocytes at the critical stage when preadipocytes become permissive for adipogenic differentiation. Furthermore, as assessed by… CONTINUE READING

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