ADAM10 mediates vascular injury induced by Staphylococcus aureus α-hemolysin.

  title={ADAM10 mediates vascular injury induced by Staphylococcus aureus α-hemolysin.},
  author={Michael E Powers and Hwan Keun Kim and Yang Wang and Juliane Bubeck Wardenburg},
  journal={The Journal of infectious diseases},
  volume={206 3},
Staphylococcus aureus is a leading cause of bacteremia and sepsis. The interaction of S. aureus with the endothelium is central to bloodstream infection pathophysiology yet remains ill-understood. We show herein that staphylococcal α-hemolysin, a pore-forming cytotoxin, is required for full virulence in a murine sepsis model. The α-hemolysin binding to its receptor A-disintegrin and metalloprotease 10 (ADAM10) upregulates the receptor's metalloprotease activity on endothelial cells, causing… CONTINUE READING


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