ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.

Abstract

E-cadherin controls a wide array of cellular behaviors, including cell-cell adhesion, differentiation, and tissue development. We show here that E-cadherin is cleaved specifically by ADAM (a disintegrin and metalloprotease) 10 in its ectodomain. Analysis of ADAM10-deficient fibroblasts, inhibitor studies, and RNA interference-mediated down-regulation of… (More)

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@article{Maretzky2005ADAM10ME, title={ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.}, author={Thorsten Maretzky and Karina Reiss and Andreas Ludwig and Julian Buchholz and Felix Scholz and Erhardt Proksch and Bart De Strooper and Dieter Hartmann and Paul Saftig}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2005}, volume={102 26}, pages={9182-7} }