ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons.

@article{Kuhn2010ADAM10IT,
  title={ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons.},
  author={Peer-Hendrik Kuhn and Huanhuan Wang and Bastian Dislich and Alessio Colombo and Ulrike Zeitschel and J. Ellwart and Elisabeth Kremmer and Steffen Ro{\ss}ner and Stefan F. Lichtenthaler},
  journal={The EMBO journal},
  year={2010},
  volume={29 17},
  pages={
          3020-32
        }
}
The amyloid precursor protein (APP) undergoes constitutive shedding by a protease activity called alpha-secretase. This is considered an important mechanism preventing the generation of the Alzheimer's disease amyloid-beta peptide (Abeta). alpha-Secretase appears to be a metalloprotease of the ADAM family, but its identity remains to be established. Using a novel alpha-secretase-cleavage site-specific antibody, we found that RNAi-mediated knockdown of ADAM10, but surprisingly not of ADAM9 or 17… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 197 CITATIONS, ESTIMATED 50% COVERAGE

407 Citations

02040'11'13'15'17'19
Citations per Year
Semantic Scholar estimates that this publication has 407 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…