ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling.

@article{Reiss2005ADAM10CO,
  title={ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling.},
  author={Karina Reiss and Thorsten Maretzky and Andreas Ludwig and Thomas A Tousseyn and Bart De Strooper and Dieter Hartmann and Paul Saftig},
  journal={The EMBO journal},
  year={2005},
  volume={24 4},
  pages={742-52}
}
Cadherins are critically involved in tissue development and tissue homeostasis. We demonstrate here that neuronal cadherin (N-cadherin) is cleaved specifically by the disintegrin and metalloproteinase ADAM10 in its ectodomain. ADAM10 is not only responsible for the constitutive, but also for the regulated, shedding of this adhesion molecule in fibroblasts and neuronal cells directly regulating the overall levels of N-cadherin expression at the cell surface. The ADAM10-induced N-cadherin… CONTINUE READING
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