ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A.

  title={ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A.},
  author={Erez Romi and Irena Gokhman and Eitan Wong and Niv Antonovsky and Andreas Ludwig and Irit Sagi and Paul Saftig and Marc Tessier-Lavigne and Avraham Yaron},
  journal={Nature communications},
During embryonic development, axons can gain and lose sensitivity to guidance cues, and this flexibility is essential for the correct wiring of the nervous system. Yet, the underlying molecular mechanisms are largely unknown. Here we show that receptor cleavage by ADAM (A Disintegrin And Metalloprotease) metalloproteases promotes murine sensory axons loss of responsiveness to the chemorepellant Sema3A. Genetic ablation of ADAM10 and ADAM17 disrupts the developmental downregulation of Neuropilin… CONTINUE READING
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