ADAM-9 is a novel mediator of tenascin-C-stimulated invasiveness of brain tumor-initiating cells.

@article{Sarkar2015ADAM9IA,
  title={ADAM-9 is a novel mediator of tenascin-C-stimulated invasiveness of brain tumor-initiating cells.},
  author={Susobhan Sarkar and Franz J. Zemp and Donna L. Senger and Stephen M. Robbins and V. Wee Yong},
  journal={Neuro-oncology},
  year={2015},
  volume={17 8},
  pages={1095-105}
}
BACKGROUND Tenascin-C (TNC), an extracellular matrix protein overexpressed in malignant gliomas, stimulates invasion of conventional glioma cell lines (U251, U87). However, there is a dearth of such information on glioma stemlike cells. Here, we have addressed whether and how TNC may regulate the invasiveness of brain tumor-initiating cells (BTICs) that give rise to glioma progenies. METHODS Transwell inserts coated with extracellular matrix proteins were used to determine the role of TNC in… CONTINUE READING
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