ADAM 12 protease induces adipogenesis in transgenic mice.

@article{Kawaguchi2002ADAM1P,
  title={ADAM 12 protease induces adipogenesis in transgenic mice.},
  author={Nobuko Kawaguchi and Xiufeng Xu and Rie Tajima and Pauliina Kronqvist and Christina Sundberg and Frosty Loechel and Reidar Albrechtsen and Ulla M. Wewer},
  journal={The American journal of pathology},
  year={2002},
  volume={160 5},
  pages={
          1895-903
        }
}
ADAM 12 (meltrin-alpha) is a member of the ADAM (a disintegrin and metalloprotease) family. ADAM 12 functions as an active metalloprotease, supports cell adhesion, and has been implicated in myoblast differentiation and fusion. Human ADAM 12 exists in two forms: the prototype membrane-anchored protein, ADAM 12-L, and a shorter secreted form, ADAM 12-S. Here we report the occurrence of adipocytes in the skeletal muscle of transgenic mice in which overexpression of either form is driven by the… CONTINUE READING

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