ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage.

@article{Roy2004ADAM1C,
  title={ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage.},
  author={Roopali Roy and Ulla M. Wewer and David Zurakowski and Susan E Pories and Marsha A Moses},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 49},
  pages={51323-30}
}
ADAM 12 is a member of a family of disintegrin-containing metalloproteases that have been implicated in a variety of diseases including Alzheimer's disease, arthritis, and cancer. We purified ADAM 12 from the urine of breast cancer patients via Q-Sepharose anion exchange and gelatin-Sepharose affinity chromatography followed by protein identification by matrix-assisted laser desorption/ionization-time of flight mass spectrometry. Four peptides were identified that spanned the amino acid… CONTINUE READING

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