ADAM 12 as a first-trimester maternal serum marker in screening for Down syndrome.

  title={ADAM 12 as a first-trimester maternal serum marker in screening for Down syndrome.},
  author={Jennie Laigaard and Kevin Sim{\~o}es Spencer and Michael Christiansen and Nicholas J. Cowans and Severin Olesen Larsen and Bent Norgaard Pedersen and Ulla M. Wewer},
  journal={Prenatal diagnosis},
  volume={26 10},
BACKGROUND A Disintegrin And Metalloprotease 12 (ADAM 12) is a glycoprotein synthesised by placenta and it has been shown to be a potential first-trimester maternal serum marker for Down syndrome (DS) in two small series. Here we analyse further, the potential of ADAM 12 as a marker for DS in a large collection of first-trimester serum samples. MATERIALS AND METHODS The concentration of ADAM 12 was determined in 10-14-week pregnancy sera from 218 DS pregnancies and 389 gestational age-matched… CONTINUE READING
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Reduction of the disintegrin and metalloprotease ADAM12 in preeclampsia

  • J Laigaard, T Sorensen, S Placing
  • Obstet Gynecol
  • 2005
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Age-standardisation for monitoring performance in Down’s syndrome screening programmes

  • H Cuckle, D Aitken, S Goodburn, B Senior, K Spencer, S. Standing
  • Prenat Diagn 24: 851–856.
  • 2004
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