ADAM 12 as a first-trimester maternal serum marker in screening for Down syndrome.

@article{Laigaard2006ADAM1A,
  title={ADAM 12 as a first-trimester maternal serum marker in screening for Down syndrome.},
  author={Jennie Laigaard and Kevin Sim{\~o}es Spencer and Michael Christiansen and Nicholas J. Cowans and Severin Olesen Larsen and Bent Norgaard Pedersen and Ulla M. Wewer},
  journal={Prenatal diagnosis},
  year={2006},
  volume={26 10},
  pages={973-9}
}
BACKGROUND A Disintegrin And Metalloprotease 12 (ADAM 12) is a glycoprotein synthesised by placenta and it has been shown to be a potential first-trimester maternal serum marker for Down syndrome (DS) in two small series. Here we analyse further, the potential of ADAM 12 as a marker for DS in a large collection of first-trimester serum samples. MATERIALS AND METHODS The concentration of ADAM 12 was determined in 10-14-week pregnancy sera from 218 DS pregnancies and 389 gestational age-matched… CONTINUE READING
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