ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3.

@article{Loechel2000ADAM1C,
  title={ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3.},
  author={Frosty Loechel and Jay William Fox and Gillian Murphy and Reidar Albrechtsen and Ulla M. Wewer},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={278 3},
  pages={511-5}
}
ADAMs are a family of multidomain proteins having proteolytic and cell adhesion activities. We have previously shown that ADAM 12-S, the secreted soluble form of human ADAM 12, is a catalytically active protease. We now describe the purification of full-length recombinant ADAM 12-S and demonstrate that it cleaves insulin-like growth factor binding protein-3 (IGFBP-3). This result supports a role for ADAM 12-S in the degradation of IGFBP-3 in the blood of pregnant women. Furthermore, we tested… CONTINUE READING

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