ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain.

@article{Wolfsberg1995ADAMAW,
  title={ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain.},
  author={Tyra G. Wolfsberg and Paul D Straight and R L Gerena and A P Huovila and Paul Primakoff and Diana Gold Myles and J Michael White},
  journal={Developmental biology},
  year={1995},
  volume={169 1},
  pages={378-83}
}
Fertilin alpha and beta, previously known as PH-30 alpha and beta, are two subunits of a guinea pig sperm integral membrane protein implicated in sperm-egg binding and fusion. They are derived from sequence-similar precursors which contain a metalloprotease-like and a disintegrin-like domain and which are related to a family of metalloprotease and disintegrin domain-containing snake venom proteins. We report here the cloning, sequencing, and characterization of mouse fertilin alpha and beta as… CONTINUE READING