ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women.

@article{Clarkson2005ACTN3GI,
  title={ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women.},
  author={Priscilla Clarkson and Joseph M. Devaney and Heather Gordish-Dressman and Paul D. Thompson and Monica Jeanne Hubal and Maria L. Urso and Thomas B. Price and Theodore J. Angelopoulos and Paul M. Gordon and Niall Moyna and Linda S. Pescatello and Paul S. Visich and Robert F. Zoeller and Richard L. Seip and Eric P. Hoffman},
  journal={Journal of applied physiology},
  year={2005},
  volume={99 1},
  pages={
          154-63
        }
}
The alpha-actinin 3 (ACTN3) gene encodes a protein of the Z disk of myofibers, and a polymorphism of ACTN3 results in complete loss of the protein. The ACTN3 genotype (R577X) has been found to be associated with performance in Australian elite athletes (Yang N, MacArthur DG, Gulbin JP, Hahn AG, Beggs AH, Easteal S, and North K. Am J Hum Genet 73: 627-631, 2003). We studied associations between ACTN3 genotype and muscle size [cross-sectional area of the biceps brachii via magnetic resonance… Expand
ACTN3 genotype is associated with muscle phenotypes in women across the adult age span.
TLDR
It is indicated that the absence of alpha-actinin-3 protein influences KE peak torque and FFM in women but not men, and the association of ACTN3 R577X genotype with muscle strength and mass phenotypes in men and women across the adult age span. Expand
ACTN3 R577X Polymorphism and Neuromuscular Response to Resistance Training.
TLDR
The R577X polymorphism at the ACTN3 gene is not associated with baseline muscle strength or with the muscle strength response to resistance training, and it appears that the R allele carriers respond better to muscle thickness gains in response to training. Expand
ACTN3 genotype and modulation of skeletal muscle response to exercise in human subjects.
TLDR
The hypothesis that ACTN3 genotype-associated differences in muscle mass and glycogen utilization provide a mechanistic explanation for the modulation of human performance by the ACTN 3 genotype is reinforced. Expand
The individual and combined influence of ACE and ACTN3 genotypes on muscle phenotypes before and after strength training
TLDR
It is shown for the first time that the ACTN3 R577X polymorphism is associated with human Vm and (independently and in combination with the ACE I/D polymorphism) influences 1‐RM and Wmax. Expand
ACTN3 polymorphism affects thigh muscle area.
TLDR
The results of the present study suggest that ACTN3 R577X polymorphism influences muscle mass in older Japanese women. Expand
Assessment of association of ACTN3 genetic polymorphism with Korean elite athletic performance
TLDR
The results imply that the sex specific ACTN3 R577X genotype may provide a significant effect on elite Korean female SPAs status, although larger sample sizes and functional studies are necessary to further elucidate these findings. Expand
ACTN3 R577X Genotype and Exercise Phenotypes in Recreational Marathon Runners
TLDR
The ACTN3 genotype might influence several exercise phenotypes in recreational marathoners, and might be accompanied by higher body fatness, lower muscle strength and higher muscle flexibility and range of motion. Expand
ACTN3 Genotypes and Their Relationship with Muscle Mass and Function of Kosovan Adults
Maintaining muscle mass and function is important throughout the lifestyle. While environmental factors such as physical activity and healthy nutrition are well investigated, the contribution ofExpand
Muscle Work and Its Relationship with ACE and ACTN3 Polymorphisms Are Associated with the Improvement of Explosive Strength
Background: The potential influence of genetics in athletic performance allows the search for genetic profiles associated with muscular work for the orientation of strength training and sportsExpand
ACTN3 genotype is associated with human elite athletic performance.
TLDR
Associations between ACTN3 genotype and athletic performance suggest that the presence of alpha-actinin-3 has a beneficial effect on the function of skeletal muscle in generating forceful contractions at high velocity, and provides an evolutionary advantage because of increased sprint performance. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 34 REFERENCES
ACTN3 genotype is associated with human elite athletic performance.
TLDR
Associations between ACTN3 genotype and athletic performance suggest that the presence of alpha-actinin-3 has a beneficial effect on the function of skeletal muscle in generating forceful contractions at high velocity, and provides an evolutionary advantage because of increased sprint performance. Expand
CNTF genotype is associated with muscular strength and quality in humans across the adult age span.
TLDR
Results indicate that individuals exhibiting the G/A genotype possess significantly greater muscular strength and muscle quality at relatively fast contraction speeds than do G/G individuals and suggest that further investigations should address the relationship between CNTF genotype and muscular power. Expand
Strength training: importance of genetic factors.
TLDR
Genetic correlations between measures of pre- and post-training strength were indicative for high pleiotropic gene action and minor activation of training-specific genes during training. Expand
Effects of age, gender, and myostatin genotype on the hypertrophic response to heavy resistance strength training.
  • F. M. Ivey, S. Roth, +9 authors B. Hurley
  • Medicine
  • The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2000
TLDR
Age does not affect the muscle mass response to either ST or detraining, whereas gender does, as men increased their muscle volume about twice as much in response to ST as did women and experienced larger losses in responseto detraining than women. Expand
Functional polymorphisms associated with human muscle size and strength.
TLDR
FAMuSS should help identify genetic factors associated with muscle performance and the response to exercise training and may also contribute to understanding better muscle physiology, to identifying individuals who are susceptible to muscle loss with environmental challenge, and to developing pharmacologic agents capable of preserving muscle size and function. Expand
Insulin-like growth factor-2 genotype, fat-free mass, and muscle performance across the adult life span.
TLDR
The hypothesis that variation within a gene known to influence developing muscle affects muscle mass and muscle function in later life is supported. Expand
Muscle hypertrophy in men and women.
TLDR
It is widely believed that women experience less skeletal muscle hypertrophy consequent to heavy-resistance training than men, but this hypothesis was tested using both traditional indirect indicators as well as a direct measure of muscle size using computed tomography scanning. Expand
Myofibrillar damage following intense eccentric exercise in man.
TLDR
The eccentric exercise gives rise to muscles soreness and influences, on mechanical basis and selectively with regard to fiber type, the fine structure of the contractile apparatus. Expand
Effects of eccentric and concentric muscle actions in resistance training.
TLDR
It is suggested that increases in peak torque and strength-related performance parameters were greater following a programme consisting of maximum concentric and eccentric muscle actions than resistance training using concentric muscle actions only. Expand
Response to resistance training in young women and men.
TLDR
The data indicate that in response to the same short-term training program, muscle size increases similarly in women and men but women make greater relative increases in strength. Expand
...
1
2
3
4
...