ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS

@article{Brodie1932ACTIVEIA,
  title={ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS},
  author={Maurice Brodie},
  journal={The Journal of Experimental Medicine},
  year={1932},
  volume={56},
  pages={493 - 505}
}
  • M. Brodie
  • Published 30 September 1932
  • Medicine
  • The Journal of Experimental Medicine
1. A single intracutaneous inoculation with a subinfective dose of the virus of poliomyelitis produces considerable immunity. 2. Virus-serum combinations produce an appreciable immunity, providing just sufficient serum is used to protect the animal from paralysis. If there is an excess of serum, the degree of immunity is considerably reduced. 
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References

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ACTIVE IMMUNIZATION AGAINST POLIOMYELITIS IN MONKEYS
TLDR
The virus neutralization test is more sensitive than the direct intracerebral test for determining the production of immunity, and is probably less effective than when it is given simultaneously with, or before, the injection of serum.
The Distribution of the Virus of Poliomyelitis in the Cerebrospinal Axis of Monkeys
TLDR
In the spinal cord, most of the neurones are affected, in the pons and medulla there may be considerable inflammatory exudate but there is decidedly less nerve cell destruction and specific changes are rarely present in the brain.
HUMAN CONVALESCENT SERUM IN THE TREATMENT OF PREPARALYTIC POLIOMYELITIS: A COMPARISON OF 447 TREATED AND 102 CONTROL PATIENTS IN NEW YORK CITY IN 1931
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The Poliomyelitis Committee of the New York Academy of Medicine attempted to estimate the value of convalescent human poliomyelinitis serum the efficacy of which had been established on the basis of Flexner and Lewis' studies on experimental animals but later it became obvious that the disease in the paralytic stage was too expensive.
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