ACTH receptor: Ectopic expression, activity and signaling

  title={ACTH receptor: Ectopic expression, activity and signaling},
  author={Fȥbio Luȷs Forti and Matheus Henrique Dos S Dias and Hugo Aguirre Armelin},
  journal={Molecular and Cellular Biochemistry},
Failure in obtaining expression of functional adrenocorticotropic hormone receptor (ACTHR, or melanocortin 2 receptor, MC2R) in non-adrenal cells has hindered molecular analysis of ACTH signaling pathways. Here, we ectopically expressed the mouse ACTHR in Balb/c mouse 3T3 fibroblasts to analyze ACTH signaling pathways involved in induction of fos and jun genes. Natural constitutive expression of the MC2R accessory protein (MRAP) in Balb3T3 and other mouse 3T3 fibroblasts (NIH, Swiss and 3T3-L1… CONTINUE READING