ACTH-producing pituitary tumors in transgenic mice. An ultrastructural and immunoelectron microscopic study.

Ultrastructural and electron microscopic immunohistochemical features of corticotropic pituitary tumors arising in polyoma large T transgenic mice and the corresponding tumor transplants in non-transgenic mice are reported. Spherical, irregular and drop-shaped secretory granules measuring 150-450 nm in diameter, were seen in all tumors. Both in tumors from… (More)