ACTH precursors characterize the ectopic ACTH syndrome.

  title={ACTH precursors characterize the ectopic ACTH syndrome.},
  author={P. M. Stewart and Scott Gibson and Steven R Crosby and Richard Penn and Roger Holder and David Ferry and Nicholas Thatcher and Peter Phillips and Dennis London and Anne R White},
  journal={Clinical endocrinology},
  volume={40 2},
OBJECTIVE ACTH is secreted by the pituitary following processing of larger molecular weight precursors, proopiomelanocortin and pro-ACTH. Ectopic ACTH syndrome refers to the secretion of ACTH by non-pituitary tumours, but the predominant circulating form of proopiomelanocortin-related peptides remains unclear. PATIENTS Fifteen patients with ectopic ACTH syndrome were compared to 20 patients with pituitary-dependent Cushing's syndrome, 22 patients with small cell lung carcinoma but no evidence… CONTINUE READING