ACTH-like peptides in postimplantation mouse embryos: a possible role in myoblast proliferation and muscle histogenesis.

@article{Angelis1992ACTHlikePI,
  title={ACTH-like peptides in postimplantation mouse embryos: a possible role in myoblast proliferation and muscle histogenesis.},
  author={Luciana de Angelis and Maria Gabriella Cusella-De Angelis and Marina Bouch{\'e} and Elisabetta Vivarelli and Carla Boitani and Mario Molinaro and Giulio Cossu},
  journal={Developmental biology},
  year={1992},
  volume={151 2},
  pages={
          446-58
        }
}
ACTH and related peptides are mitogens for certain mesodermal cell types such as adrenocortical cells, T-lymphocytes, and skeletal myoblasts. In order to postulate a possible physiological role for these peptides in skeletal muscle histogenesis, it is necessary to establish whether they are present in muscle forming anlagens of postimplantation mouse embryos. By radioimmunoassay and immunofluorescence with antibodies specific for ACTH, we have detected these peptides in many areas of mouse… CONTINUE READING
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