ACTH hypertension modifies the haemodynamic effects of prostacyclin infusions in sheep.


1. The haemodynamic effects of short-term prostacyclin infusions (0.05-0.50 microgram/kg per min) were investigated in conscious adult sheep. 2. Haemodynamic dose-response curves to prostacyclin were performed before, during and after production of ACTH-induced hypertension. 3. Prior to ACTH administration prostacyclin produced dose-dependent reductions in… (More)


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