ACTH does not control neonatal seizures induced by administration of exogenous corticotropin-releasing hormone.

@article{Baram1995ACTHDN,
  title={ACTH does not control neonatal seizures induced by administration of exogenous corticotropin-releasing hormone.},
  author={Tallie Z. Baram and Linda Schultz},
  journal={Epilepsia},
  year={1995},
  volume={36 2},
  pages={174-8}
}
ACTH has been used extensively for treatment of massive infantile spasms (MIS) and other intractable seizures. The mechanisms by which ACTH exerts anticonvulsant effects are unknown. ACTH is a neuropeptide with both endocrine and neuromodulatory properties; its efficacy against MIS could derive from intrinsic anticonvulsant properties or from hormonal effects, either directly or through glucocorticoids. We tested ACTH activity against exogenous corticotropin-releasing hormone (CRH)-induced… CONTINUE READING