ACTH and PMX53 recover synaptic transcriptome alterations in a rat model of infantile spasms

@inproceedings{Iacobas2018ACTHAP,
  title={ACTH and PMX53 recover synaptic transcriptome alterations in a rat model of infantile spasms},
  author={Dumitru Andrei Iacobas and Tamar Chachua and Sanda Iacobaş and Melissa J. Benson and Karin Borges and Jana Vel{\'i}{\vs}kov{\'a} and Libor Vel{\'i}{\vs}ek},
  booktitle={Scientific Reports},
  year={2018}
}
We profiled the gene expression in the hypothalamic arcuate nuclei (ARC) of 20 male and 20 female rats to determine the infantile spasms (IS) related transcriptomic alteration of neurotransmission and recovery following two treatments. Rats were prenatally exposed to betamethasone or saline followed by repeated postnatal subjection to NMDA-triggered IS… CONTINUE READING