ACTH and α-MSH inhibit leptin expression and secretion in 3T3-L1 adipocytes: model for a central–peripheral melanocortin-leptin pathway

@article{Norman2003ACTHA,
  title={ACTH and $\alpha$-MSH inhibit leptin expression and secretion in 3T3-L1 adipocytes: model for a central–peripheral melanocortin-leptin pathway},
  author={D. Norman and A. Isidori and V. Frajese and M. Caprio and A. Fabbri},
  journal={Molecular and Cellular Endocrinology},
  year={2003},
  volume={200},
  pages={99-109}
}
Leptin is the 167 amino-acid protein product of the Lep (obese) gene that is released predominantly from adipose tissue and circulates at levels related to the amount of fat. Leptin expression is hormonally regulated: insulin and glucocorticoids are stimulators, while inhibitors include beta-adrenergic agonists and testosterone. Recently, adenylate cyclase-coupled melanocortin receptors have been identified in murine adipose tissue, the 3T3-L1 adipocyte cell line, and in human fat tissue. These… Expand
Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes
Leptin and the hypothalamo-pituitary-adrenal stress axis.
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