ACT-6, a novel plasmid-encoded class C β-lactamase in a Klebsiella pneumoniae isolate from China

@article{Zhu2011ACT6AN,
  title={ACT-6, a novel plasmid-encoded class C β-lactamase in a Klebsiella pneumoniae isolate from China},
  author={Yulin Zhu and Xiao-Ni Zhang and Fan Gao and Jun Cheng and Li-fen Hu and Tai Ma and Jun Yin and Ying Ye and Jia-Bin Li},
  journal={The Journal of Antibiotics},
  year={2011},
  volume={64},
  pages={317-320}
}
The purpose of this study was to investigate the phenotypic and molecular characterization of a novel plasmid-mediated AmpC-type β-lactamase in Klebsiella pneumoniae E701 isolated from Anhui province in China. In comparison with the ACT-1, sequence analysis revealed that there were 43 point mutations in the coding gene, and 10 of which led to amino-acid substitution. Resistance could be transferred by conjugation or transformation with plasmid DNA into E. coli JM109, which was due to the… CONTINUE READING