ACK1/TNK2 Tyrosine Kinase: Molecular Signaling and Evolving Role in Cancers

@inproceedings{Mahajan2015ACK1TNK2TK,
  title={ACK1/TNK2 Tyrosine Kinase: Molecular Signaling and Evolving Role in Cancers},
  author={Kiran N. Mahajan and Nupam P. Mahajan},
  booktitle={Oncogene},
  year={2015}
}
Deregulated tyrosine kinase signaling alters cellular homeostasis to drive cancer progression. The emergence of a non-receptor tyrosine kinase (non-RTK), ACK1 (also known as activated Cdc42-associated kinase 1 or TNK2) as an oncogenic kinase, has uncovered novel mechanisms by which tyrosine kinase signaling promotes cancer progression. Although early studies focused on ACK1 as a cytosolic effector of activated transmembrane RTKs, wherein it shuttles between the cytosol and the nucleus to… CONTINUE READING

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Cell NucleusIs associated anatomy of gene productEstrogen Receptors
Although early studies focused on ACK1 as a cytosolic effector of activated transmembrane RTKs , wherein it shuttles between the cytosol and the nucleus to rapidly transduce extracellular signals from the RTKs to the intracellular effectors , recent data unfold a new aspect of its functionality as an epigenetic regulator . ACK1 interacts with the estrogen receptor ( ER)/histone demethylase KDM3A ( JHDM2a ) complex , which modifies KDM3A by tyrosine phosphorylation to regulate the transcriptional outcome at HOXA1 locus to promote the growth of tamoxifen - resistant breast cancer .
Cell NucleusIs associated anatomy of gene productestrogen receptor alpha, human
Although early studies focused on ACK1 as a cytosolic effector of activated transmembrane RTKs , wherein it shuttles between the cytosol and the nucleus to rapidly transduce extracellular signals from the RTKs to the intracellular effectors , recent data unfold a new aspect of its functionality as an epigenetic regulator . ACK1 interacts with the estrogen receptor ( ER)/histone demethylase KDM3A ( JHDM2a ) complex , which modifies KDM3A by tyrosine phosphorylation to regulate the transcriptional outcome at HOXA1 locus to promote the growth of tamoxifen - resistant breast cancer .
EstrogensContraindicated with diseaseMammary Neoplasms
Although early studies focused on ACK1 as a cytosolic effector of activated transmembrane RTKs , wherein it shuttles between the cytosol and the nucleus to rapidly transduce extracellular signals from the RTKs to the intracellular effectors , recent data unfold a new aspect of its functionality as an epigenetic regulator . ACK1 interacts with the estrogen receptor ( ER)/histone demethylase KDM3A ( JHDM2a ) complex , which modifies KDM3A by tyrosine phosphorylation to regulate the transcriptional outcome at HOXA1 locus to promote the growth of tamoxifen - resistant breast cancer .
The emergence of a non - receptor tyrosine kinase ( non - RTK ) , ACK1 ( also known as activated Cdc42-associated kinase 1 or TNK2 ) as an oncogenic kinase , has uncovered novel mechanisms by which tyrosine kinase signaling promotes cancer progression .
The emergence of a non - receptor tyrosine kinase ( non - RTK ) , ACK1 ( also known as activated Cdc42-associated kinase 1 or TNK2 ) as an oncogenic kinase , has uncovered novel mechanisms by which tyrosine kinase signaling promotes cancer progression .
The emergence of a non - receptor tyrosine kinase ( non - RTK ) , ACK1 ( also known as activated Cdc42-associated kinase 1 or TNK2 ) as an oncogenic kinase , has uncovered novel mechanisms by which tyrosine kinase signaling promotes cancer progression .
ACK1/TNK2 Tyrosine Kinase : Molecular Signaling and Evolving Role in Cancers . Deregulated tyrosine kinase signaling
The emergence of a non - receptor tyrosine kinase ( non - RTK ) , ACK1 ( also known as activated Cdc42-associated kinase 1 or TNK2 ) as an oncogenic kinase , has uncovered novel mechanisms by which tyrosine kinase signaling promotes cancer progression .
The emergence of a non - receptor tyrosine kinase ( non - RTK ) , ACK1 ( also known as activated Cdc42-associated kinase 1 or TNK2 ) as an oncogenic kinase , has uncovered novel mechanisms by which tyrosine kinase signaling promotes cancer progression .
The emergence of a non - receptor tyrosine kinase ( non - RTK ) , ACK1 ( also known as activated Cdc42-associated kinase 1 or TNK2 ) as an oncogenic kinase , has uncovered novel mechanisms by which tyrosine kinase signaling promotes cancer progression .
ACK1/TNK2 Tyrosine Kinase : Molecular Signaling and Evolving Role in Cancers . Deregulated tyrosine kinase signaling
Although early studies focused on ACK1 as a cytosolic effector of activated transmembrane RTKs , wherein it shuttles between the cytosol and the nucleus to rapidly transduce extracellular signals from the RTKs to the intracellular effectors , recent data unfold a new aspect of its functionality as an epigenetic regulator . ACK1 interacts with the estrogen receptor ( ER)/histone demethylase KDM3A ( JHDM2a ) complex , which modifies KDM3A by tyrosine phosphorylation to regulate the transcriptional outcome at HOXA1 locus to promote the growth of tamoxifen - resistant breast cancer .
Although early studies focused on ACK1 as a cytosolic effector of activated transmembrane RTKs , wherein it shuttles between the cytosol and the nucleus to rapidly transduce extracellular signals from the RTKs to the intracellular effectors , recent data unfold a new aspect of its functionality as an epigenetic regulator . ACK1 interacts with the estrogen receptor ( ER)/histone demethylase KDM3A ( JHDM2a ) complex , which modifies KDM3A by tyrosine phosphorylation to regulate the transcriptional outcome at HOXA1 locus to promote the growth of tamoxifen - resistant breast cancer .
Although early studies focused on ACK1 as a cytosolic effector of activated transmembrane RTKs , wherein it shuttles between the cytosol and the nucleus to rapidly transduce extracellular signals from the RTKs to the intracellular effectors , recent data unfold a new aspect of its functionality as an epigenetic regulator . ACK1 interacts with the estrogen receptor ( ER)/histone demethylase KDM3A ( JHDM2a ) complex , which modifies KDM3A by tyrosine phosphorylation to regulate the transcriptional outcome at HOXA1 locus to promote the growth of tamoxifen - resistant breast cancer .
It is also well established that ACK1 regulates the activity of androgen receptor ( AR ) by tyrosine phosphorylation to fuel the growth of hormone - refractory prostate cancers .
Although early studies focused on ACK1 as a cytosolic effector of activated transmembrane RTKs , wherein it shuttles between the cytosol and the nucleus to rapidly transduce extracellular signals from the RTKs to the intracellular effectors , recent data unfold a new aspect of its functionality as an epigenetic regulator . ACK1 interacts with the estrogen receptor ( ER)/histone demethylase KDM3A ( JHDM2a ) complex , which modifies KDM3A by tyrosine phosphorylation to regulate the transcriptional outcome at HOXA1 locus to promote the growth of tamoxifen - resistant breast cancer .
The emergence of a non - receptor tyrosine kinase ( non - RTK ) , ACK1 ( also known as activated Cdc42-associated kinase 1 or TNK2 ) as an oncogenic kinase , has uncovered novel mechanisms by which tyrosine kinase signaling promotes cancer progression .
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