ACET is a highly potent and specific kainate receptor antagonist: Characterisation and effects on hippocampal mossy fibre function

@article{Dargan2009ACETIA,
  title={ACET is a highly potent and specific kainate receptor antagonist: Characterisation and effects on hippocampal mossy fibre function},
  author={Sheila L. Dargan and Vernon R. J. Clarke and Gregory M Alushin and John L. Sherwood and Graham L Collingridge},
  journal={Neuropharmacology},
  year={2009},
  volume={56},
  pages={121-130}
}
Kainate receptors (KARs) are involved in both NMDA receptor-independent long-term potentiation (LTP) and synaptic facilitation at mossy fibre synapses in the CA3 region of the hippocampus. However, the identity of the KAR subtypes involved remains controversial. Here we used a highly potent and selective GluK1 (formerly GluR5) antagonist (ACET) to elucidate roles of GluK1-containing KARs in these synaptic processes. We confirmed that ACET is an extremely potent GluK1 antagonist, with a Kb value… CONTINUE READING
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