ACEA 1021, a glycine site antagonist with minor psychotomimetic and amnestic effects in rats.

@article{Kretschmer1997ACEA1A,
  title={ACEA 1021, a glycine site antagonist with minor psychotomimetic and amnestic effects in rats.},
  author={Beate D. Kretschmer and Ulrich Kratzer and K Breithecker and Michael Koch},
  journal={European journal of pharmacology},
  year={1997},
  volume={331 2-3},
  pages={109-16}
}
Antagonists of the allosteric glycine site of the NMDA receptor complex have been suggested to be beneficial in the treatment of neurodegenerative disorders. However, unwanted side effects like psychomotor stimulation and amnesia must be expected. ACEA 1021 (5-nitro-6,7-dichloro-1,4-dihydroquioxaline-2,3dione) is one of the first high-selective glycine site antagonists which passes the blood-brain barrier and which has promising anticonvulsive and neuroprotective properties. In the present… CONTINUE READING
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