ACE2, an activator of yeast metallothionein expression which is homologous to SWI5.

@article{Butler1991ACE2AA,
  title={ACE2, an activator of yeast metallothionein expression which is homologous to SWI5.},
  author={G. Butler and Dennis J Thiele},
  journal={Molecular and cellular biology},
  year={1991},
  volume={11 1},
  pages={476-85}
}
Transcription of the Saccharomyces cerevisiae metallothionein gene CUP1 is induced in response to high environmental levels of copper. Induction requires the ACE1 gene product, which binds to specific sites in the promoter region of the CUP1 gene. In this study, we found that deleting the entire coding sequence of the ACE1 gene resulted in a decrease in basal-level transcription of CUP1 to low but detectable levels and conferred a copper-sensitive phenotype to the cells. We have isolated a gene… CONTINUE READING

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