ACE insertion/deletion genotype affects bradykinin metabolism.

  title={ACE insertion/deletion genotype affects bradykinin metabolism.},
  author={Nancy J. Brown and Charles Blais and Sanya K. Gandhi and Albert Adam},
  journal={Journal of cardiovascular pharmacology},
  volume={32 3},
A deletion allele of the angiotensin-converting enzyme (ACE) gene has been associated with increased serum ACE activity, enhanced conversion of angiotensin (Ang) I to Ang II, and cardiovascular morbidity. This study tested the hypothesis that the ACE deletion allele is also associated with enhanced degradation of bradykinin, a vasoprotective peptide. Metabolism of synthetic bradykinin was measured in sera obtained from subjects who were homozygous for either the ACE deletion (n=12) or insertion… CONTINUE READING

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