ACE inhibitors versus AT(1) receptor antagonists in patients with chronic renal disease.

  title={ACE inhibitors versus AT(1) receptor antagonists in patients with chronic renal disease.},
  author={Karl Friedrich Hilgers and Johannes F. E. Mann},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={13 4},
The success of Angiotensin-converting enzyme (ACE) inhibitors in preventing the progression of chronic renal insufficiency has led investigators to study the effects of other inhibitors of the renin-angiotensin system (RAS). Recently, the results of the first large-scale trials with angiotensin II type 1 receptor (AT1) antagonists became available (1,2). This article discusses the relative merits of ACE inhibitors, AT1 antagonists, and the combination of both drug classes in the treatment of… CONTINUE READING


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