ACE inhibition reduces proteinuria, glomerular lesions and extracellular matrix production in a normotensive rat model of immune complex nephritis.

@article{RuizOrtega1995ACEIR,
  title={ACE inhibition reduces proteinuria, glomerular lesions and extracellular matrix production in a normotensive rat model of immune complex nephritis.},
  author={Marta Ruiz-Ortega and Susana Rodr{\'i}guez Gonz{\'a}lez and Daniel Ser{\'o}n and Enric Condom and C. Bustos and Raquel Largo and Ernesto Gonz{\'a}lez and Alberto Ortiz and Jes{\'u}s Egido},
  journal={Kidney international},
  year={1995},
  volume={48 6},
  pages={
          1778-91
        }
}
We studied the effect of the angiotensin converting enzyme (ACE) inhibitor, quinapril, on the clinical and morphological lesions of a normotensive model of immune complex nephritis. Untreated rats developed massive nephrotic syndrome, intense cell proliferation and glomerular and tubulointerstitial lesions. In the renal cortex of nephritic rats there was a significant increase in gene expression of TGF-beta 1, fibronectin and collagens, and ACE activity. Systolic blood pressure remained normal… CONTINUE READING

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