ACE inhibition and AT1 receptor blockade prevent fatty liver and fibrosis in obese Zucker rats.

@article{Toblli2008ACEIA,
  title={ACE inhibition and AT1 receptor blockade prevent fatty liver and fibrosis in obese Zucker rats.},
  author={J E Toblli and Marina Cecilia Mu{\~n}oz and Gabriel Cao and Jos{\'e} Manuel Mella and Lisandro Pereyra and Ricardo Cesar Mastai},
  journal={Obesity},
  year={2008},
  volume={16 4},
  pages={770-6}
}
OBJECTIVE Non-alcoholic steatohepatitis (NASH), which is a common liver disease in industrialized countries, is associated with obesity, hypertension, and type-2 diabetes (metabolic syndrome). Since angiotensin II (ANG II) has been suggested to play an important role in liver inflammation and fibrosis, the purpose of this study was to investigate whether therapy against renin-angiotensin system (RAS) may provide some beneficial effect in liver of an animal model of metabolic syndrome. METHODS… CONTINUE READING

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