ACE inhibition: postsynaptic adrenergic sympatholytic action in men.

@article{Lyons1997ACEIP,
  title={ACE inhibition: postsynaptic adrenergic sympatholytic action in men.},
  author={Denise M. Lyons and Shane Roy and Sharon O'Byrne and Cameron G. Swift},
  journal={Circulation},
  year={1997},
  volume={96 3},
  pages={911-5}
}
BACKGROUND The mechanisms by which ACE inhibitors produce a sustained clinical benefit are not entirely clear but may involve the sympathetic nervous system. We compared the effect of local brachial artery infusions of an ACE inhibitor (perindoprilat) with the effect of placebo (0.9% NaCl) on endogenously mediated (lower body negative pressure [LBNP]) and exogenously mediated (brachial artery infusions of norepinephrine) sympathetic vasoconstriction. METHODS AND RESULTS Eight healthy… CONTINUE READING