ACE gene polymorphism and renal scar in children with acute pyelonephritis

@article{Cho2002ACEGP,
  title={ACE gene polymorphism and renal scar in children with acute pyelonephritis},
  author={Su Jin Cho and Seung Jae Lee},
  journal={Pediatric Nephrology},
  year={2002},
  volume={17},
  pages={491-495}
}
The pathogenesis of renal scarring after acute pyelonephritis (APN) in children is multifactorial. In addition to well-known risk factors (young age, high grade of vesicoureteral reflux, P-fimbriated Escherichia coli, and treatment delay), a role for genetic predisposition has been suggested. Since the ACE gene deletion polymorphism is a known risk factor for progressive glomerulosclerosis in chronic renal diseases, we have investigated the relationship between the ACE genotypes and the… CONTINUE READING
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