ACCELERATED COMMUNICATION Control of Glutamate Receptor 2 (GluR2) Translational Initiation by Its Alternative 3 Untranslated Regions

Abstract

Four major glutamate receptor 2 (GluR2) transcripts differing in size ( 4 and 6 kilobases) due to alternative 3 untranslated regions (UTRs), and also containing alternative 5 UTRs, exist in the brain. Both the long 5 UTR and long 3 UTR repress translation of GluR2 mRNA; repression by the 3 UTR is relieved after seizures. To understand the mechanism of… (More)

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