ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites.

@article{Sasaki2012ACBD3mediatedRO,
  title={ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites.},
  author={Jun Sasaki and Kumiko Ishikawa and Minetaro Arita and Koki Taniguchi},
  journal={The EMBO journal},
  year={2012},
  volume={31 3},
  pages={754-66}
}
Phosphatidylinositol 4-kinase IIIβ (PI4KB) is a host factor required for genome RNA replication of enteroviruses, small non-enveloped viruses belonging to the family Picornaviridae. Here, we demonstrated that PI4KB is also essential for genome replication of another picornavirus, Aichi virus (AiV), but is recruited to the genome replication sites by a different strategy from that utilized by enteroviruses. AiV non-structural proteins, 2B, 2BC, 2C, 3A, and 3AB, interacted with a Golgi protein… CONTINUE READING
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