ABT-627, an endothelin ET(A) receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain.

@article{Jarvis2000ABT627AE,
  title={ABT-627, an endothelin ET(A) receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain.},
  author={Michael F. Jarvis and Jerry L Wessale and Chang Zhen Zhu and James J. Lynch and Brian D Dayton and Samuel V Calzadilla and Robert J. Padley and Terry J. Opgenorth and Elizabeth A Kowaluk},
  journal={European journal of pharmacology},
  year={2000},
  volume={388 1},
  pages={29-35}
}
Tactile allodynia, the enhanced perception of pain in response to normally non-painful stimulation, represents a common complication of diabetic neuropathy. The activation of endothelin ET(A) receptors has been implicated in diabetes-induced reductions in peripheral neurovascularization and concomitant endoneurial hypoxia. Endothelin receptor activation has also been shown to alter the peripheral and central processing of nociceptive information. The present study was conducted to evaluate the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

Similar Papers

Loading similar papers…