ABSTINENCE SYMPTOMS AFTER WITHDRAWAL OF TRANQUILLISING DRUGS: IS THERE A COMMON NEUROCHEMICAL MECHANISM?

@article{Cowen1982ABSTINENCESA,
  title={ABSTINENCE SYMPTOMS AFTER WITHDRAWAL OF TRANQUILLISING DRUGS: IS THERE A COMMON NEUROCHEMICAL MECHANISM?},
  author={Philip J. Cowen and David J. Nutt},
  journal={The Lancet},
  year={1982},
  volume={320},
  pages={360-362}
}
Withdrawal of anxiolytic agents such as ethanol, barbiturates, and benzodiazepines may result in a syndrome characterised in its most severe form by delirium and seizures. There is increasing evidence that anxiolytic drugs produce their pharmacological effects by enhancing brain gamma-aminobutyric acid (GABA) transmission. During long-term exposure to anxiolytics, brain GABA synapses show evidence of adaptive changes which would tend to reduce the effect of the anxiolytic and restore normal… Expand
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