ABSTINENCE SYMPTOMS AFTER WITHDRAWAL OF TRANQUILLISING DRUGS: IS THERE A COMMON NEUROCHEMICAL MECHANISM?

@article{Cowen1982ABSTINENCESA,
  title={ABSTINENCE SYMPTOMS AFTER WITHDRAWAL OF TRANQUILLISING DRUGS: IS THERE A COMMON NEUROCHEMICAL MECHANISM?},
  author={P. Cowen and D. Nutt},
  journal={The Lancet},
  year={1982},
  volume={320},
  pages={360-362}
}
Withdrawal of anxiolytic agents such as ethanol, barbiturates, and benzodiazepines may result in a syndrome characterised in its most severe form by delirium and seizures. There is increasing evidence that anxiolytic drugs produce their pharmacological effects by enhancing brain gamma-aminobutyric acid (GABA) transmission. During long-term exposure to anxiolytics, brain GABA synapses show evidence of adaptive changes which would tend to reduce the effect of the anxiolytic and restore normal… Expand
Alcohol withdrawal and carbamazepine.
Overexcitement and disinhibition. Dynamic neurotransmitter interactions in alcohol withdrawal.
  • P. Glue, D. Nutt
  • Psychology, Medicine
  • The British journal of psychiatry : the journal of mental science
  • 1990
Benzodiazepine Dependence
Neuropharmacological and clinical aspects of alcohol withdrawal.
Pharmacotherapy for anxiety disorders: drugs available
Benzodiazepine-serotonin interactions in man.
The EEG in hypnosedative drug withdrawal and dependence
  • B. Sweden
  • Psychology
  • European archives of psychiatry and neurological sciences
  • 2004
Substitution therapy for alcoholism: time for a reappraisal?
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 24 REFERENCES
Alcohol withdrawal reactions in mice: effects of drugs that modify neurotransmission.
  • D. B. Goldstein
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1973
Diagnosis and management of depressant drug dependence.
GABA‐Benzodiazepine‐Barbiturate Receptor Interactions
  • R. Olsen
  • Chemistry, Medicine
  • Journal of neurochemistry
  • 1981
Sleep and its Disorders
Addiction to diazepam.
...
1
2
3
...