ABO incompatible kidney transplantations without splenectomy, using antigen-specific immunoadsorption and rituximab.

@article{Tydn2005ABOIK,
  title={ABO incompatible kidney transplantations without splenectomy, using antigen-specific immunoadsorption and rituximab.},
  author={Gunnar Tyd{\'e}n and Gunilla Kumlien and Helena Genberg and John Sandberg and Torbj{\"o}rn Lundgren and Ingela Fehrman},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2005},
  volume={5 1},
  pages={145-8}
}
ABO incompatible kidney transplantations have previously only been performed after several preoperative sessions of plasmapheresis and splenectomy, with the conventional triple-drug immunosuppressive protocol being reinforced with antilymphocyte globulin and B-cell-specific drugs, such as cyclophosphamide or deoxyspergualine. We have designed a protocol without splenectomy, based on antigen-specific immunoadsorption, rituximab and a conventional triple-drug immunosuppressive protocol. The… CONTINUE READING