ABCC5 is required for cAMP-mediated hindgut invagination in sea urchin embryos.

Abstract

ATP-binding cassette (ABC) transporters are evolutionarily conserved proteins that pump diverse substrates across membranes. Many are known to efflux signaling molecules and are extensively expressed during development. However, the role of transporters in moving extracellular signals that regulate embryogenesis is largely unexplored. Here, we show that a… (More)
DOI: 10.1242/dev.126144

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