ABCC5 is required for cAMP-mediated hindgut invagination in sea urchin embryos.

@article{Shipp2015ABCC5IR,
  title={ABCC5 is required for cAMP-mediated hindgut invagination in sea urchin embryos.},
  author={Lauren Elizabeth Shipp and Rose Z Hill and Gary W. Moy and Tufan G{\"o}kırmak and Amro Hamdoun},
  journal={Development},
  year={2015},
  volume={142 20},
  pages={
          3537-48
        }
}
ATP-binding cassette (ABC) transporters are evolutionarily conserved proteins that pump diverse substrates across membranes. Many are known to efflux signaling molecules and are extensively expressed during development. However, the role of transporters in moving extracellular signals that regulate embryogenesis is largely unexplored. Here, we show that a mesodermal ABCC (MRP) transporter is necessary for endodermal gut morphogenesis in sea urchin embryos. This transporter, Sp-ABCC5a (C5a), is… CONTINUE READING
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