ABCC4 is regulated by microRNA-124a and microRNA-506.

  title={ABCC4 is regulated by microRNA-124a and microRNA-506.},
  author={Svetlana M Markova and Deanna L. Kroetz},
  journal={Biochemical pharmacology},
  volume={87 3},
Multidrug resistance protein 4 (MRP4, ABCC4) is an efflux membrane transporter expressed in renal tubules, hepatocytes, brain capillaries, prostate and blood cells. MRP4 drives energy dependent efflux of important physiological and pharmacological compounds. MRP4 expression and function is highly variable but cannot be fully attributed to known mechanisms. The goal of this study was to characterize ABCC4 regulation by miRNAs and to assess the influence of ABCC4 3'-UTR polymorphisms on ABCC4… CONTINUE READING


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