ABCC2 (1249G > A) polymorphism implicates altered transport activity for sorafenib.

Abstract

1. Multidrug resistance-associated protein 2 (MRP2), encoded by the ABCC2 gene, is an efflux transporter of several endogenous substrates and xenobiotics. Here, we investigated whether the 1249G > A (rs2273697) polymorphism in ABCC2 affects the ability of MRP2 to pump the multi-tumor drug sorafenib out of cells. 2. Human embryonic kidney 293 (HEK 293) cell… (More)
DOI: 10.1080/00498254.2016.1262976

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