ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier.

@article{Bronger2005ABCCDE,
  title={ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier.},
  author={Holger Bronger and J. Frank Koenig and Kathrin Kopplow and H G Steiner and Rezvan Ahmadi and Christel Herold-Mende and Dietrich Keppler and Anne T Nies},
  journal={Cancer research},
  year={2005},
  volume={65 24},
  pages={11419-28}
}
Delivery of therapeutic agents to the brain and its neoplasms depends on the presence of membrane transport proteins in the blood-brain barrier and in the target cells. The cellular and subcellular localization of these membrane transporters determines the drug accessibility to the brain and its tumors. We therefore analyzed the expression and localization of six members of the multidrug resistance protein family of ATP-dependent efflux pumps (ABCC1-ABCC6, formerly MRP1-MRP6) and of six organic… CONTINUE READING

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