ABCB6, an ABC Transporter Impacting Drug Response and Disease

  title={ABCB6, an ABC Transporter Impacting Drug Response and Disease},
  author={Rebba C. Boswell-Casteel and Yu Fukuda and John D. Schuetz},
  journal={The AAPS Journal},
Recent findings have discovered how insufficiency of ATP-binding cassette (ABC) transporter, ABCB6, can negatively impact human health. These advances were made possible by, first, finding that ABCB6 deficiency was the genetic basis for some severe transfusion reactions and by, second, determining that functionally impaired ABCB6 variants enhanced the severity of porphyria, i.e., diseases associated with defects in heme synthesis. ABCB6 is a broad-spectrum porphyrin transporter that is capable… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 60 references

A heme-binding domain controls regulation of ATP-dependent potassium channels.

Proceedings of the National Academy of Sciences of the United States of America • 2016
View 1 Excerpt

A mechanism of viral immune evasion revealed by cryoEM ana l y s i s o f t h e TAP t r an spo r t e r

ML Oldham, RK Hite, +3 authors T Walz
Na t u r e . 2016;529(7587):537–40 • 2016

Similar Papers

Loading similar papers…