ABCB1 polymorphisms correlate with susceptibility to adult acute leukemia and response to high-dose methotrexate

@article{Ma2015ABCB1PC,
  title={ABCB1 polymorphisms correlate with susceptibility to adult acute leukemia and response to high-dose methotrexate},
  author={Chuan-Xiang Ma and Yong-Hong Sun and Hai-Ying Wang},
  journal={Tumor Biology},
  year={2015},
  volume={36},
  pages={7599-7606}
}
The aim of this study is to investigate the association of ABCB1 polymorphisms with susceptibility to adult acute leukemia, and the influence of ABCB1 polymorphisms on the efficacy of high-dose methotrexate (HDMTX). ABCB1 polymorphisms in 178 acute leukemia patients (case group) and 150 healthy subjects (control group) were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. All patients received HDMTX therapy. Correlation analysis was performed to… CONTINUE READING

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