ABCB1 genotypes and haplotypes in patients with dementia and age-matched non-demented control patients

@article{Frankfort2006ABCB1GA,
  title={ABCB1 genotypes and haplotypes in patients with dementia and age-matched non-demented control patients},
  author={Suzanne V Frankfort and Valerie D Doodeman and Remco Bakker and Linda R. Tulner and Jos P. C. M. van Campen and Paul H. M. Smits and Jos H. Beijnen},
  journal={Molecular Neurodegeneration},
  year={2006},
  volume={1},
  pages={13 - 13}
}
Amyloid β is an in vitro substrate for P-glycoprotein (P-gp), an efflux pump at the blood brain barrier (BBB). The Multi Drug Resistance (ABCB1) gene, encoding for P-gp, is highly polymorphic and this may result in a changed function of P-gp and may possibly interfere with the pathogenesis of Alzheimer's disease. This study investigates to what extent ABCB1 Single Nucleotide Polymorphisms (SNPs; C1236T in exon 12, G2677T/A in exon 21 and C3435T in exon 26) and inferred haplotypes exist in an… CONTINUE READING