ABCB1 genotypes and haplotypes in patients with dementia and age-matched non-demented control patients

@article{Frankfort2006ABCB1GA,
  title={ABCB1 genotypes and haplotypes in patients with dementia and age-matched non-demented control patients},
  author={S. V. Frankfort and V. Doodeman and R. Bakker and L. Tulner and J. V. van Campen and P. Smits and J. Beijnen},
  journal={Molecular Neurodegeneration},
  year={2006},
  volume={1},
  pages={13 - 13}
}
  • S. V. Frankfort, V. Doodeman, +4 authors J. Beijnen
  • Published 2006
  • Medicine
  • Molecular Neurodegeneration
  • Amyloid β is an in vitro substrate for P-glycoprotein (P-gp), an efflux pump at the blood brain barrier (BBB). The Multi Drug Resistance (ABCB1) gene, encoding for P-gp, is highly polymorphic and this may result in a changed function of P-gp and may possibly interfere with the pathogenesis of Alzheimer's disease. This study investigates to what extent ABCB1 Single Nucleotide Polymorphisms (SNPs; C1236T in exon 12, G2677T/A in exon 21 and C3435T in exon 26) and inferred haplotypes exist in an… CONTINUE READING
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