ABCB1 gene polymorphisms are associated with the severity of major depressive disorder and its response to escitalopram treatment.

@article{Lin2011ABCB1GP,
  title={ABCB1 gene polymorphisms are associated with the severity of major depressive disorder and its response to escitalopram treatment.},
  author={K A Lin and Yen-Feng Chiu and I-Ju Tsai and Chia-Hui Chen and Winston Wu-Dien Shen and Shu Chih Liu and S. Lu and Chia-Yih Liu and Mei-Chun Hsiao and Hwa-Sheng Tang and Shen-Ing Liu and Liang-Huey Chang and Chi-Shin Wu and H H Tsou and Ming-Hsien Tsai and Chun-Yu Chen and Su-mei Wang and Hsiang-Wei Kuo and Ya-Ting Hsu and Yu-Li Liu},
  journal={Pharmacogenetics and genomics},
  year={2011},
  volume={21 4},
  pages={163-70}
}
OBJECTIVE ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) is a drug transporter protein expressed on the epithelial cells of the intestine and the endothelial cells of the blood-brain barrier. Intestinal ABCB1 actively transports drugs from the cell membrane and prevents them from entering the blood stream whereas the blood-brain barrier ABCB1 prevents drugs from entering the central nervous system. In this study, we tested whether genetic polymorphisms within the ABCB1 gene are… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS