ABCB1 and cytochrome P450 polymorphisms: clinical pharmacogenetics of clozapine.

  title={ABCB1 and cytochrome P450 polymorphisms: clinical pharmacogenetics of clozapine.},
  author={Eveline Jaquenoud Sirot and Branka Kne{\vz}evi{\'c} and Gina Perla Morena and Sabine Harenberg and Beatrice Oneda and Severine Crettol and Nicolas Ansermot and Pierre Baumann and Chin B. Eap},
  journal={Journal of clinical psychopharmacology},
  volume={29 4},
To examine the genetic factors influencing clozapine kinetics in vivo, 75 patients treated with clozapine were genotyped for CYPs and ABCB1 polymorphisms and phenotyped for CYP1A2 and CYP3A activity. CYP1A2 activity and dose-corrected trough steady-state plasma concentrations of clozapine correlated significantly (r = -0.61; P = 1 x 10), with no influence of the CYP1A2*1F genotype (P = 0.38). CYP2C19 poor metabolizers (*2/*2 genotype) had 2.3-fold higher (P = 0.036) clozapine concentrations… CONTINUE READING

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