ABCB1 and ABCC3 gene polymorphisms are associated with first-year response to methotrexate in juvenile idiopathic arthritis.

@article{Rotte2012ABCB1AA,
  title={ABCB1 and ABCC3 gene polymorphisms are associated with first-year response to methotrexate in juvenile idiopathic arthritis.},
  author={Maurits C J F de Rotte and Maja Bulatovi{\'c} and Marloes W. Heijstek and Gerrit Jansen and Sandra G. Heil and Ron H. N. van Schaik and Nico Martinus Wulffraat and Robert de Jonge},
  journal={The Journal of rheumatology},
  year={2012},
  volume={39 10},
  pages={2032-40}
}
OBJECTIVE Although methotrexate (MTX) is the most widely prescribed drug in juvenile idiopathic arthritis (JIA), 30% of patients fail to respond to it. To individualize treatment strategies, the genetic determinants of response to MTX should be identified. METHODS A cohort of 287 patients with JIA treated with MTX was studied longitudinally over the first year of treatment. MTX response was defined as the American College of Rheumatology pediatric 70 criteria (ACRped70). We genotyped 21… CONTINUE READING
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