ABCB1 G2677 allele is associated with high dose requirement of cyclosporin A to prevent renal allograft rejection in North India.

@article{Singh2008ABCB1GA,
  title={ABCB1 G2677 allele is associated with high dose requirement of cyclosporin A to prevent renal allograft rejection in North India.},
  author={Ranjana Singh and Pravin Kesarwani and Aneesh Srivastava and Rama Devi Mittal},
  journal={Archives of medical research},
  year={2008},
  volume={39 7},
  pages={695-701}
}
BACKGROUND Interindividual heterogeneity in expression of ABCB1 gene has been suspected to be one of the factors resulting in cyclosporin (CsA) pharmacokinetic variation. The present study explored the association of ABCB1 SNPs on CsA dose requirements and dose-adjusted C2 levels (CsA level/daily dose requirement) in renal allograft recipients. METHODS Daily doses (mg/kg/day) and dose-adjusted C2 levels (microg/mL per mg/kg/day) at 1 and 3 months for 155 recipients on CsA therapy were… CONTINUE READING